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生物医药论坛:纤毛虫原生动物表观遗传学--高珊
发布时间:2020-12-04   作者:




报告题目: 纤毛虫原生动物表观遗传学

报 告 人: 高珊 教授(中国海洋大学)

报告时间: 2020年12月7日 (星期一) 14:00-16:00
报告地点: 云南大学呈贡校区力行楼1301



个人简介:

高珊,中国海洋大学海洋生命学院教授,博士生导师,国家“万人计划”青年拔尖人才,国家优秀青年基金获得者。以单细胞真核模式生物--嗜热四膜虫(Tetrahymena thermophila)为研究体系,从事表观遗传学研究,主要兴趣包括:1)DNA腺嘌呤甲基化(6mA)的功能和分子机制;2)复制-转录冲突的表观遗传调控机制。

代表性论文:

  1. Yuanyuan Wang, Yalan Sheng, Yongqiang Liu, Wenxin Zhang, Ting Cheng, Lili Duan, Bo Pan, Yu Qiao, Yifan Liu, Shan Gao* (2019). A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription. Nucleic Acids Research, 47, 11771-11789.

  2. Xiaolu Zhao, Jie Xiong, Fengbiao Mao, Yalan Sheng, Xiao Chen, Lifang Feng, Wen Dui, Wentao Yang, Aurelie Kapusta, Cedric Feschotte, Rebert S. Coyne, Wei Miao, Shan Gao*, Yifan Liu* (2019). RNAidependent Polycomb repression controls transposable elements in Tetrahymena. Genes & Development, 33, 348-364.

  3. Xiao Chen, Yurui Wang, Yalan Sheng, Alan Warren, Shan Gao* (2018). GPSit: An automated method for evolutionary analysis of nonculturable ciliated microeukaryotes. Molecular Ecology Resources, 18,700-713.

  4. Yuanyuan Wang, Xiao Chen, Yalan Sheng, Yifan Liu, Shan Gao* (2017). N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol IItranscribed genes in Tetrahymena. Nucleic Acids Research, 45, 11594-11606.

  5. Shan Gao#, Jie Xiong#, Chunchao Zhang, Brian R. Berquist, Rendong Yang, Meng Zhao, Anthony J. Molascon, Shaina Y. Kwiatkowski, Dongxia Yuan, Zhaohui Qin, Jianfen Wen, Geoffrey M. Kapler, Philip C. Andrews, Wei Miao, Yifan Liu (2013). Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes & Development, 27, 1662-1679.


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